KRAS scientific papers
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Ras oncogenes: the first 30 years
Malumbres M & Barbacid M. Nature Rev 2003; 3: 7-13.
Malumbres & Barbacid give a historical perspective of RAS oncogenes, from the initial discovery of oncogenes in the 1960s to a current understanding of their role in cell signaling cascades.
Initially, the paper reviews the early work on oncogenes and the discovery of RAS, which led to an understanding of the mechanisms of action and provided an understanding of the biochemistry of signal transduction involving RAS (including KRAS). The authors then review more recent work on RAS post-translational modification and explain how information from 3D structure aids our growing understanding of function. The paper concludes with a discussion of possible avenues for future research, while examining possible medical benefits of an understanding of RAS oncogenes.
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Hyperactive Ras in developmental disorders and cancer
Schubbert S, Shannon K & Bollag G. Nature Rev 2007; 7: 295-308.
Schubbert et al discuss the emerging understanding of the role of RAS in both developmental biology and tumorigenesis.
The authors detail recent research findings into the cell biology of RAS and the effects of mutations on tumor development. Recently germline mutations in signaling cascades have been identified which have increased our understanding of the components that make up the pathways and relate to their role in cancer. The biochemistry and function of the mutant proteins encoded by RAS is explored; the principles of RAS regulation, and how they relate to signal transduction, is explained.
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